Chinese officials and scientists have denounced the claims of a geneticist who said he had created the first gene-edited babies.
Authorities have ordered an investigation as a hospital linked to the research suggested its ethical approval had been forged.
The National Health Commission said on Monday it was "highly concerned" and had ordered provincial health officials "to immediately investigate and clarify the matter".
"The biomedical ethics review for this so-called research exists in name only. Conducting direct human experiments can only be described as crazy," the Chinese-language letter, signed by approximately 120 scientists, says.
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